Add a setting to disable column profiling altogether
There is no way (as of Jun 2019) to fully disable column profiling. The problem is that complex queries can take a long time to execute and the column profiling header bar at the top of each column can take minute or hours of processing to show the color-coded green bar. All the while, it's eating up database resources and making PQ run slower.
Matt Allington commented
I agree, but it should be a workbook setting, not a default setting.